Holly Edwards Selected Research

voruciclib

1/2020

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia.

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Holly Edwards Research Topics

Disease

24	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 11/2010
7	Neoplasms (Cancer) 01/2019 - 01/2013
4	Down Syndrome (Down's Syndrome) 01/2022 - 01/2011
4	Leukemia 08/2020 - 09/2009
4	Pancreatic Neoplasms (Pancreatic Cancer) 07/2017 - 12/2014
3	Acute Megakaryoblastic Leukemia (Leukemia, Megakaryocytic) 01/2013 - 09/2009
2	Neuroblastoma 01/2015 - 01/2013
2	Epilepsy (Aura) 12/2012 - 11/2010
1	Infections 01/2022
1	Myeloid Leukemia (Leukemia, Myelocytic) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019
1	Carcinogenesis 01/2019
1	Diffuse Intrinsic Pontine Glioma 01/2017
1	Disease Progression 01/2017

Drug/Important Bio-Agent (IBA)

9	venetoclaxIBA 01/2021 - 01/2016
7	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2022 - 11/2010
6	PanobinostatIBA 01/2017 - 01/2013
5	Histone Deacetylase InhibitorsIBA 01/2020 - 11/2010
5	Histone Deacetylases (Histone Deacetylase)IBA 01/2020 - 02/2011
4	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2013
4	adavosertibIBA 01/2015 - 08/2014
3	CUDC-907IBA 01/2021 - 11/2019
3	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2011
2	obatoclaxIBA 02/2015 - 12/2014
2	Pharmaceutical PreparationsIBA 01/2013 - 11/2010
2	Valproic Acid (Depakote)FDA LinkGeneric 12/2012 - 11/2010
1	CohesinsIBA 01/2022
1	fms-Like Tyrosine Kinase 3IBA 01/2021
1	IACS-010759IBA 08/2020
1	voruciclibIBA 01/2020
1	Androgen Receptors (Androgen Receptor)IBA 01/2020
1	gilteritinibIBA 11/2019
1	midostaurinIBA 11/2019
1	Intercalating AgentsIBA 01/2019
1	Propidium (Propidium Iodide)IBA 01/2019
1	RNA Polymerase I (Polymerase I, RNA)IBA 01/2019
1	Annexin A5IBA 01/2019
1	vosaroxinIBA 01/2019
1	Topoisomerase II InhibitorsIBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2018
1	Reactive Nitrogen SpeciesIBA 07/2018
1	VS-5584IBA 07/2017
1	SCH772984IBA 07/2017
1	Gemcitabine FDA Link 06/2017
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 06/2017
1	dipinacoline glutamateIBA 01/2017
1	piperlongumineIBA 01/2016
1	AnthracyclinesIBA 02/2015
1	Chloroquine (Aralen)FDA LinkGeneric 12/2014
1	Phosphotransferases (Kinase)IBA 10/2014
1	Cisplatin (Platino)FDA LinkGeneric 01/2013
1	Transcription Factors (Transcription Factor)IBA 01/2013
1	Etoposide (VP 16)FDA LinkGeneric 01/2013
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2013
1	LY2603618IBA 01/2013
1	Clofarabine (Clolar)FDA Link 12/2012
1	Purine NucleosidesIBA 12/2012
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 09/2009

Therapy/Procedure

10	Therapeutics 01/2022 - 01/2011
10	Drug Therapy (Chemotherapy) 01/2022 - 09/2009
1	Castration 01/2020
1	Induction Chemotherapy 01/2019
1	Re-Irradiation 01/2017